Disease models - Latest News | Preclinical CRO Syncrosome

Syncrosome: poster Preclinical PAH Sugen – European Respiratory Society meeting

Pulmonary arterial hypertension (PAH) is a rare cardiopulmonary disorder characterized by progressive obliteration of small pulmonary arterioles that leads to increased pulmonary vascular resistance. Because of impaired blood flow inpulmonary arteries, right ventricular pressure (RVSP) rises, ultimately leading toright ventricular failure and premature death. This...

26 janvier, 2017 / 0 Comments

Alpha synuclein Parkinson disease and pure autonomic failure in patients

To characterize the expression in skin nerves of native (n-syn) and misfolded phosphorylated (p-syn) α-synucleins in pure autonomic failure (PAF) and idiopathic Parkinson disease (IPD). The specific aims were to (1) define the importance of n-syn and p-syn as disease biomarkers and (2) ascertain differences...

17 janvier, 2017 / 0 Comments

Novel therapeuthic target against Ulcerative Colitis-Crohn disease in a mouse IBD model

Temperature sensitive anti-inflammatory Novel therapeuthic target against IBD Ulcerative colitis (UC) together with Crohn’s disease (CD), are Inflammatory bowel diseases (mouse IBD). The chronic and relapsing inflammation of all or part of the digestive tract causes severe diarrhea, pain, fatigue and weight loss. Researchers currently...

10 janvier, 2017 / 0 Comments

Happy New Year 2017

Syncrosome is happy to wish you all the best for 2017! ...

03 janvier, 2017 / 0 Comments

Syncrosome: what did we change in 2016?

The end of 2016 is near, and with the closure of this year comes the joy of Christmas, holidays and celebrations, but before we head off to spend time with our families, we would like to thank you for your devotion throughout 2016. Let’s remember...

23 décembre, 2016 / 0 Comments

Mouse ischemia reperfusion: a good preclinical model for myocardial infarction?

Myocardial infarction (MI) results from a biphasic ischemia/reperfusion (I/R) injury to the heart. The disease is linked to cardiomyocyte apoptosis and further along to inflammation-based tissue damage. Despite considerable effort, therapeutic interventions to disrupt this injury pattern are not optimal. Indeed, the inflammation's multifactorial nature complicates...

12 décembre, 2016 / 0 Comments

SYNCROSOME CIR accreditation

For more than 6 years now, Syncrosome has worked as a preclinical CRO accredited by the French Ministry of Higher Education and Research for Research Tax Credits (CIR). Our recognition procures a significant financial benefit for French companies wishing to pursue their R & D work in Cardiovascular, Central...

09 décembre, 2016 / 0 Comments

Organ cross talk in DSS induced colitis can be effectively treated with anti-inflammatory molecule

Inflammatory bowel disease (IBD), consisting of Crohn’s disease (CD) and ulcerative colitis (UC), involves chronic inflammation of all or part of the digestive tract and millions are affected around the world. Researchers currently believe that an unregulated immune response to resident intestinal bacteria, influenced by...

01 décembre, 2016 / 0 Comments

Syncrosome sets up a new preclinical PAH (Pulmonary Arterial Hypertension) model in mouse.

Pulmonary arterial hypertension (PAH) is a syndrome in which pulmonary arterial obstruction increases pulmonary vascular resistance, leading to right ventricular hypertrophy (RVH), failure, and death. The development of small-animal preclinical models of PAH is a necessary challenge in order to test the efficacy of new...

23 novembre, 2016 / 0 Comments

Syncrosome keeps increasing its In vivo Preclinical skills

In the framework of our development, we are proud to announce the recruitment of our new scientific colleague, Guénaelle CANET. She will work in our Technical Department at the Lab and will be in charge, with the scientific and technical team, of setting up different...

15 novembre, 2016 / 0 Comments

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