Respiratory preclinical

Disease Models

NEWS

    Syncrosome provides a wide range of screening models in respiratory preclinical disease with a focus expertise on inflammatory diseases including Chronic Obstructive Pulmonary Disease (COPD), Asthma, Cough. Our disease models (ferrets, rats or mice depending on the pathology) are fitted for testing disease-modifying drug or compounds acting on symptomatic effects. Following your needs, it is possible to perform classical, Intranasal or Intratracheal (powder and liquid) administration or to use a nebulizer.

    Respiratory preclinical disease models

    We perform symptomatic read out such as whole body plethysmography (tidal volume, respiratory rate, expiration time, respiratory flows, PenH, etc…) and special software analysis. We associated to these parameters the study of specific biomarkers by Histology and/or ELISA (Cellular biomarkers, cytokines). This combination of different techniques makes us the ideal partners for a quick answer about the potential efficacy of your compounds on respiratory pathologies with high content studies.

    Our respiratory department also has the knowledge and skills to evaluate security aspects in parallel with efficacy studies on the same species and at the same time.
    We offer you the possibility to screen your compound with simplified protocols, allowing you to save time in the development of your potential new drug.

    • Allergy, Ovalbumin induction
    • Number of Eosinophils in broncho-alveolar lavage (BAL) and % of eosinophils of total white cells
    • Respiratory parameters (Whole Body Plethysmography)
    • Cytokine level assessment (IL5, IL4, IL13, …,)
    • Inflammation, LPS induction
    • Number of Neutrophils in bronchoalveolar lavage (BAL) and % of neutrophils of total white cells
    • Respiratory parameters (Whole Body Plethysmography)
    • Cytokine level assessment (IL1, IL8, IL6, TNF-alpha, …,)
    • Chemical induction
    • Number of cough
    • Respiratory parameters

    Download our disease models specifications