Temperature sensitive anti-inflammatory Novel therapeuthic target against IBD Ulcerative colitis (UC) together with Crohn’s disease (CD), are Inflammatory bowel diseases (mouse IBD). The chronic and relapsing inflammation of all or part of the digestive tract causes severe diarrhea, pain, fatigue and weight loss. Researchers currently...
The end of 2016 is near, and with the closure of this year comes the joy of Christmas, holidays and celebrations, but before we head off to spend time with our families, we would like to thank you for your devotion throughout 2016. Let’s remember...
Myocardial infarction (MI) results from a biphasic ischemia/reperfusion (I/R) injury to the heart. The disease is linked to cardiomyocyte apoptosis and further along to inflammation-based tissue damage. Despite considerable effort, therapeutic interventions to disrupt this injury pattern are not optimal. Indeed, the inflammation's multifactorial nature complicates...
For more than 6 years now, Syncrosome has worked as a preclinical CRO accredited by the French Ministry of Higher Education and Research for Research Tax Credits (CIR). Our recognition procures a significant financial benefit for French companies wishing to pursue their R & D work in Cardiovascular, Central...
Inflammatory bowel disease (IBD), consisting of Crohn’s disease (CD) and ulcerative colitis (UC), involves chronic inflammation of all or part of the digestive tract and millions are affected around the world. Researchers currently believe that an unregulated immune response to resident intestinal bacteria, influenced by...
Pulmonary arterial hypertension (PAH) is a syndrome in which pulmonary arterial obstruction increases pulmonary vascular resistance, leading to right ventricular hypertrophy (RVH), failure, and death. The development of small-animal preclinical models of PAH is a necessary challenge in order to test the efficacy of new...
In the framework of our development, we are proud to announce the recruitment of our new scientific colleague, Guénaelle CANET. She will work in our Technical Department at the Lab and will be in charge, with the scientific and technical team, of setting up different...
Researchers from the college of Pharmaceutical Sciences in China have recently studied a compound that enhances neuronal recovery in a rat model of Parkinson’s disease (Parkinson 6 OHDA). Parkinson’s disease is a chronic disorder of the central nervous system, caused primarily by the progressive loss...
Emesis and/or Nausea are commonly reported side effects associated with several drugs such as 4 phosphodiesterase (PDE4) inhibitors and is a major drawback for the therapeutic use of these drugs. The mechanism responsible for this side effect has been investigated in an attempt to discover...