Understanding Dyskinesia in 6 OHDA rats Parkinson preclinical model
The pathophysiological mechanisms leading to Dyskinesia in Parkinson’s preclinical models (PD) after long-term treatment with levodopa remain unclear.
14 mars, 2017
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Nordic Day Syncrosome
The last january, all the Syncrosome laboratory an commercial team participated on a 2-day team building event in the French Alpes. It was an enthusiastic "scientific and sportive" experience for everyone! After different meetings to exchange on topics like: Important scientific and commercial results obtained in 2016, ...
01 mars, 2017
Echocardiographic preclinical studies of Congestive heart failure
Congestive heart failure (CHF) is a serious outcome of myocardial infarction (MI). Animal models have been used to study various aspects of CHF. Postinfarction animal models have been extensively studied because myocardial ischemia and infarction are frequent causes of CHF in humans. However, not all...
14 février, 2017
Mechanism behind memory impairment caused by LPS neuro-inflammation
Alzheimer's disease (AD) is a progressive neuro-psychiatric disorder which is characterized by the formation of senile plaques (SPs), extracellular deposits of amyloid beta-peptides (Aβ) following intracellular neurofibrillary tangles (NFTs) of the microtubule-associated protein tau. Both cause neuronal degeneration, extensive loss of neurons and synaptic loss...
07 février, 2017
Syncrosome in French Alpes for a Special Nordic Team Event
January 2017 is a great month for all the Syncrosome Laboratory and Commercial team. On Sunday 29th of January, all the team will be leaving for the French Alpes on a 2-day Team building experience. Our goal is to summarize Syncrosome’s 2016 life and events to...
26 janvier, 2017
Syncrosome: poster Preclinical PAH Sugen – European Respiratory Society meeting
Pulmonary arterial hypertension (PAH) is a rare cardiopulmonary disorder characterized by progressive obliteration of small pulmonary arterioles that leads to increased pulmonary vascular resistance. Because of impaired blood flow inpulmonary arteries, right ventricular pressure (RVSP) rises, ultimately leading toright ventricular failure and premature death. This...
26 janvier, 2017
Alpha synuclein Parkinson disease and pure autonomic failure in patients
To characterize the expression in skin nerves of native (n-syn) and misfolded phosphorylated (p-syn) α-synucleins in pure autonomic failure (PAF) and idiopathic Parkinson disease (IPD). The specific aims were to (1) define the importance of n-syn and p-syn as disease biomarkers and (2) ascertain differences...
17 janvier, 2017
Novel therapeuthic target against Ulcerative Colitis-Crohn disease in a mouse IBD model
Temperature sensitive anti-inflammatory Novel therapeuthic target against IBD Ulcerative colitis (UC) together with Crohn’s disease (CD), are Inflammatory bowel diseases (mouse IBD). The chronic and relapsing inflammation of all or part of the digestive tract causes severe diarrhea, pain, fatigue and weight loss. Researchers currently...
10 janvier, 2017
Syncrosome: what did we change in 2016?
The end of 2016 is near, and with the closure of this year comes the joy of Christmas, holidays and celebrations, but before we head off to spend time with our families, we would like to thank you for your devotion throughout 2016. Let’s remember...
23 décembre, 2016