Central Nervous System

Syncrosome at the next NeuroFrance Congress in Marseille

SYNCROSOME your dedicated partner for In Vivo Efficacy Studies has been accepted for a poster presentation at NeuroFrance 2019 (Marseille, France, 22-24 May) which is an International Meeting from Société des Neurosciences. Thanks to its CNS expertise our CNS Study Monitor, Dr. Delphine Revy, will present several...

Syncrosome & the Translational Neuroscience Congress

As you know Syncrosome is a preclinical CRO managing efficacy in vivo/ in vitro studies with more than 15 disease models validated in house and highly reproducible. Syncrosome is involved in Central Nervous System activities for 16 years with a specific department dedicated to several CNS...

Meta analysis of mesenchymal stem cells in preclinical Parkinson models

Multiple studies have been performed to evaluate the effects of mesenchymal stem cells (MSCs) in preclinical Parkinson models. We performed a meta-analysis to estimate the treatment effect of unmodified MSCs on behavioral outcomes in preclinical studies of Parkinson's disease (PD). We performed a systematic literature search...

Mechanism behind memory impairment caused by LPS neuro-inflammation

Alzheimer's disease (AD) is a progressive neuro-psychiatric disorder which is characterized by the formation of senile plaques (SPs), extracellular deposits of amyloid beta-peptides (Aβ) following intracellular neurofibrillary tangles (NFTs) of the microtubule-associated protein tau. Both cause neuronal degeneration, extensive loss of neurons and synaptic loss...

Alpha synuclein Parkinson disease and pure autonomic failure in patients

To characterize the expression in skin nerves of native (n-syn) and misfolded phosphorylated (p-syn) α-synucleins in pure autonomic failure (PAF) and idiopathic Parkinson disease (IPD). The specific aims were to (1) define the importance of n-syn and p-syn as disease biomarkers and (2) ascertain differences...

BACK from the 2nd Annual Neuroscience R&D Technologies Conference

Syncrosome, participated last week to the Neuroscience R&D Technologies Conference in London, to present key Parkinson's data. It was 2 very interesting days spent to discuss about the new advances in Imaging of Neurodegeneration, Alzheimer and Parkinson’s Disease and Drug Discovery, New trends in Preclinical animal...

NEW RATING SCALE OF AIMs IN OUR L-DOPA INDUCED DYSKINESIAS RAT MODEL

L-DOPA remains the most effective therapy in the management of the motor symptoms of Parkinson's disease (PD). However, chronic treatment with levodopa is associated with the risk of development of motor fluctuations such as choreic and dystonic abnormal and involuntary movements affecting mainly the upper...

Immunization therapies, synuclein and Parkinson’s disease – multiple system atrophy

Vaccination is increasingly being investigated as a potential treatment for synucleinopathies, a group of neurodegenerative diseases including Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies associated with α-synuclein pathology. All lack a causal therapy. Development of novel, disease-altering treatment strategies is urgently needed....