Cardiovascular

New services from SYNCROSOME

SYNCROSOME provides frozen or fixed slices of different tissues mounted on slides  from several preclinical models. PAH models (Monocrotaline or SuHxNx) LUNGS and HEART (right and left ventricle) PLASMA samples   HEART FAILURE models (Isoproterenol or Myocardial infarction) HEART (right and left ventricles)   PARKINSON models (6-OHDA and Lactacystine): BRAIN   ASTHMA...

New preclinical models of Heart Failure presented at the last edition of the GRRC

The participation to the « Spring of Cardiology » offered to Syncrosome the opportunity to present its expertise in the cardiovascular field: development of preclinical models of heart failure and evaluation of cardiac remodelling and function by 2D-echocardiography to assess the efficacy of new therapeutic strategies. Since 2016,...

Echocardiographic preclinical studies of Congestive heart failure

Congestive heart failure (CHF) is a serious outcome of myocardial infarction (MI). Animal models have been used to study various aspects of CHF. Postinfarction animal models have been extensively studied because myocardial ischemia and infarction are frequent causes of CHF in humans. However, not all...

Syncrosome: poster Preclinical PAH Sugen – European Respiratory Society meeting

Pulmonary arterial hypertension (PAH) is a rare cardiopulmonary disorder characterized by progressive obliteration of small pulmonary arterioles that leads to increased pulmonary vascular resistance. Because of impaired blood flow inpulmonary arteries, right ventricular pressure (RVSP) rises, ultimately leading toright ventricular failure and premature death. This...

Mouse ischemia reperfusion: a good preclinical model for myocardial infarction?

Myocardial infarction (MI) results from a biphasic ischemia/reperfusion (I/R) injury to the heart. The disease is linked to cardiomyocyte apoptosis and further along to inflammation-based tissue damage. Despite considerable effort, therapeutic interventions to disrupt this injury pattern are not optimal. Indeed, the inflammation's multifactorial nature complicates...

Poster PAH sugen – ERS meeting

Below a poster presented by Syncrosome during the last European Respiratory Society meeting showing interesting result concerning Pulmonary Arterial Hypertension induced on rats with Sugen with remodeling in small pulmonary arteries (PAH sugen). Results are reproducible and shows a vascular remodeling, increased Right Ventricular Systolic Pressure...