Central Nervous System

Intracerebral administration in rat and mouse

If you need to perform intracerebral administration of your test compound, SYNCROSOME provides stereotaxic surgery in rats and mice to perform acute or chronic administration in specific brain areas and in cerebrospinal fluid in lateral ventricles.   [button size='' style='' text='Contact us' icon='fa-chevron-right' icon_color='' link='https://www.syncrosome.com/contact-us' target='_self' color=''...

NEWS for CNS Department

Nose-to-brain delivery allows application of drugs at the roof of the nasal cavity, which are transported to the central nervous system (CNS) of humans (A) and rodents (B). Nose-to-brain transport can either be mediated via the olfactory or the trigeminal pathway. Drugs passing along the olfactory...

New services from SYNCROSOME

SYNCROSOME provides frozen or fixed slices of different tissues mounted on slides  from several preclinical models. PAH models (Monocrotaline or SuHxNx) LUNGS and HEART (right and left ventricle) PLASMA samples   HEART FAILURE models (Isoproterenol or Myocardial infarction) HEART (right and left ventricles)   PARKINSON models (6-OHDA and Lactacystine): BRAIN   ASTHMA...

Syncrosome at the next NeuroFrance Congress in Marseille

SYNCROSOME your dedicated partner for In Vivo Efficacy Studies has been accepted for a poster presentation at NeuroFrance 2019 (Marseille, France, 22-24 May) which is an International Meeting from Société des Neurosciences. Thanks to its CNS expertise our CNS Study Monitor, Dr. Delphine Revy, will present several...

Syncrosome & the Translational Neuroscience Congress

As you know Syncrosome is a preclinical CRO managing efficacy in vivo/ in vitro studies with more than 15 disease models validated in house and highly reproducible. Syncrosome is involved in Central Nervous System activities for 16 years with a specific department dedicated to several CNS...

Meta analysis of mesenchymal stem cells in preclinical Parkinson models

Multiple studies have been performed to evaluate the effects of mesenchymal stem cells (MSCs) in preclinical Parkinson models. We performed a meta-analysis to estimate the treatment effect of unmodified MSCs on behavioral outcomes in preclinical studies of Parkinson's disease (PD). We performed a systematic literature search...

Mechanism behind memory impairment caused by LPS neuro-inflammation

Alzheimer's disease (AD) is a progressive neuro-psychiatric disorder which is characterized by the formation of senile plaques (SPs), extracellular deposits of amyloid beta-peptides (Aβ) following intracellular neurofibrillary tangles (NFTs) of the microtubule-associated protein tau. Both cause neuronal degeneration, extensive loss of neurons and synaptic loss...

Alpha synuclein Parkinson disease and pure autonomic failure in patients

To characterize the expression in skin nerves of native (n-syn) and misfolded phosphorylated (p-syn) α-synucleins in pure autonomic failure (PAF) and idiopathic Parkinson disease (IPD). The specific aims were to (1) define the importance of n-syn and p-syn as disease biomarkers and (2) ascertain differences...

Parkinson 6 OHDA preclinical: New POC on rat to repair neurons, with new compound.

Researchers from the college of Pharmaceutical Sciences  in China have recently studied a compound that enhances neuronal recovery in a rat model of Parkinson’s disease (Parkinson 6 OHDA). Parkinson’s disease is a chronic disorder of the central nervous system, caused primarily by the progressive loss...